No. TD dependant status permits residence and study but confers no work authorization at any point, so a spouse cannot take American employment, freelance, or work remotely for a Canadian employer from inside the United States. Employment requires a status of the spouse's own that allows it.
TD is a residence permission, not an employment one
This limitation surprises households more than any other feature of TN, partly because other categories treat spouses differently. An L-2 or E-2 spouse is employment-authorized incident to status; a TD spouse is not, and no application converts a TD into a working status. If Marguerite's husband intends to keep earning, the household has three realistic options: he pursues his own status on his own facts, he continues working for a Canadian employer while remaining based in Canada, or the family accepts a single income for the duration.
Two further details shape the planning. The relationship must be a marriage recognized in law, since a common-law partner does not qualify as a spouse for derivative purposes and would need an independent route. A child qualifies for TD only while unmarried and under 21, so a household with a teenager approaching that birthday should map it against the requested period before anyone applies rather than discovering it at renewal.