No. Spouse and unmarried children under 21 qualify as derivatives under either the standard or reduced investment amount; the targeted employment area question affects the capital amount, not family eligibility.
Targeted employment area status affects capital, not family derivative eligibility
Whether an EB-5 investment is made at the standard amount or the reduced targeted employment area amount has no bearing on which family members can accompany the investor. In either case, the investor's spouse and unmarried children under 21 qualify as derivative beneficiaries, subject to age-out considerations for children approaching 21 during processing. What does matter for a family relying on a claimed targeted employment area designation is making sure that designation is actually verified before the investment is made and the family's plans are built around it, since a mistaken or unsupported targeted employment area claim could affect the underlying investment's validity and, in turn, the entire family's path to conditional and then full permanent residence, not just the investor's own filing.
For children approaching the boundary, statutory provisions exist that can in defined circumstances protect a child's age during specified periods, and their application depends on the facts and on visa availability, so the calculation should be done by someone qualified rather than estimated.